diff --git a/CMakeLists.txt b/CMakeLists.txt
index 9686ecbea..a0605e41b 100644
--- a/CMakeLists.txt
+++ b/CMakeLists.txt
@@ -2429,6 +2429,77 @@ elseif(PSP)
       pspvram
       GL
     )
+
+elseif(OS2)
+  list(APPEND EXTRA_CFLAGS "-DOS2EMX_PLAIN_CHAR")
+  list(APPEND EXTRA_CFLAGS "-DBUILD_SDL")
+
+  file(GLOB CORE_SOURCES ${SDL2_SOURCE_DIR}/src/core/os2/*.c)
+  set(SOURCE_FILES ${SOURCE_FILES} ${CORE_SOURCES})
+  if(NOT (HAVE_ICONV AND HAVE_ICONV_H))
+    file(GLOB CORE_SOURCES ${SDL2_SOURCE_DIR}/src/core/os2/geniconv/*.c)
+    set(SOURCE_FILES ${SOURCE_FILES} ${CORE_SOURCES})
+  endif()
+
+  if(SDL_THREADS)
+    set(SDL_THREAD_OS2 1)
+    file(GLOB OS2_THREAD_SOURCES ${SDL2_SOURCE_DIR}/src/thread/os2/*.c)
+    set(SOURCE_FILES ${SOURCE_FILES} ${OS2_THREAD_SOURCES})
+    set(HAVE_SDL_THREADS TRUE)
+  endif()
+
+  if(SDL_TIMERS)
+    set(SDL_TIMER_UNIX 1)
+    file(GLOB OS2_TIMER_SOURCES ${SDL2_SOURCE_DIR}/src/timer/os2/*.c)
+    set(SOURCE_FILES ${SOURCE_FILES} ${OS2_TIMER_SOURCES})
+    set(HAVE_SDL_TIMERS TRUE)
+  endif()
+
+  if(SDL_LOADSO)
+    set(SDL_LOADSO_OS2 1)
+    file(GLOB OS2_LOADSO_SOURCES ${SDL2_SOURCE_DIR}/src/loadso/os2/*.c)
+    set(SOURCE_FILES ${SOURCE_FILES} ${OS2_LOADSO_SOURCES})
+    set(HAVE_SDL_LOADSO TRUE)
+  endif()
+
+  if(SDL_FILESYSTEM)
+    set(SDL_FILESYSTEM_OS2 1)
+    file(GLOB FILESYSTEM_SOURCES ${SDL2_SOURCE_DIR}/src/filesystem/os2/*.c)
+    set(SOURCE_FILES ${SOURCE_FILES} ${FILESYSTEM_SOURCES})
+    set(HAVE_SDL_FILESYSTEM TRUE)
+  endif()
+
+  if(SDL_LOCALE)
+    file(GLOB LOCALE_SOURCES ${SDL2_SOURCE_DIR}/src/locale/unix/*.c)
+    set(SOURCE_FILES ${SOURCE_FILES} ${LOCALE_SOURCES})
+    set(HAVE_SDL_LOCALE TRUE)
+  endif()
+
+  if(SDL_VIDEO)
+    set(SDL_VIDEO_DRIVER_OS2 1)
+    file(GLOB OS2_VIDEO_SOURCES ${SDL2_SOURCE_DIR}/src/video/os2/*.c)
+    set(SOURCE_FILES ${SOURCE_FILES} ${OS2_VIDEO_SOURCES})
+    set(HAVE_SDL_VIDEO TRUE)
+  endif()
+
+  if(SDL_AUDIO)
+    set(SDL_AUDIO_DRIVER_OS2 1)
+    file(GLOB OS2_AUDIO_SOURCES ${SDL2_SOURCE_DIR}/src/audio/os2/*.c)
+    set(SOURCE_FILES ${SOURCE_FILES} ${OS2_AUDIO_SOURCES})
+    set(HAVE_SDL_AUDIO TRUE)
+    list(APPEND EXTRA_LIBS mmpm2)
+  endif()
+
+  if(SDL_JOYSTICK)
+    set(SDL_JOYSTICK_OS2 1)
+    file(GLOB OS2_JOYSTICK_SOURCES ${SDL2_SOURCE_DIR}/src/joystick/os2/*.c)
+    set(SOURCE_FILES ${SOURCE_FILES} ${OS2_JOYSTICK_SOURCES})
+    set(HAVE_SDL_JOYSTICK TRUE)
+  endif()
+
+  if(SDL_HIDAPI)
+    CheckHIDAPI()
+  endif()
 endif()
 
 if(SDL_VULKAN AND NOT SDL_LOADSO)
@@ -2937,7 +3008,7 @@ if(NOT (WINDOWS OR CYGWIN) OR MINGW)
   if(SDL_SHARED)
     set(SOEXT ${CMAKE_SHARED_LIBRARY_SUFFIX}) # ".so", ".dylib", etc.
     get_target_property(SONAME SDL2 OUTPUT_NAME)
-    if(NOT ANDROID AND NOT MINGW)
+    if(NOT ANDROID AND NOT MINGW AND NOT OS2)
         install(CODE "
           execute_process(COMMAND ${CMAKE_COMMAND} -E create_symlink
             \"lib${SONAME}${SOPOSTFIX}${SOEXT}\" \"libSDL2${SOPOSTFIX}${SOEXT}\"
diff --git a/cmake/sdlchecks.cmake b/cmake/sdlchecks.cmake
index a5c0ec1a9..17d99b076 100644
--- a/cmake/sdlchecks.cmake
+++ b/cmake/sdlchecks.cmake
@@ -1170,6 +1170,8 @@ macro(CheckHIDAPI)
         set(CMAKE_C_FLAGS "${CMAKE_C_FLAGS} ${LIBUSB_CFLAGS}")
         if(HIDAPI_ONLY_LIBUSB)
           list(APPEND EXTRA_LIBS ${LIBUSB_LIBS})
+        elseif(OS2)
+          set(SDL_LIBUSB_DYNAMIC "\"usb100.dll\"")
         else()
           # libusb is loaded dynamically, so don't add it to EXTRA_LIBS
           FindLibraryAndSONAME("usb-1.0")